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butabarbital will reduce the level or outcome of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Effect of coadministering a robust CYP3A4 inducer with fedratinib hasn't been studied.butabarbital will reduce the extent or outcome of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabo